Solutions for me were mapping the tablet during drawing to one screen only, and making the switch to Manga Studio 5 (Clip Studio) for my line art. I did notice Lazy Nezumi caused the frazzles to look worse, because the lines are so nicely drawn, and the frazzles stand out more.
![lazy nezumi pro clip studio lazy nezumi pro clip studio](http://lazy-nezumi.ru/images/articles/min_Lazy_Nezumi_Pro_id969579.gif)
And that causes frazzles when working zoomed out. In my case I use an older Intuos 1 tablet with three screens - with a screen setup of 2x2540 pixels and 25% zoom, approximately 1 tablet point per screen pixel is available. There is a simple reason for the jaggies: when you draw zoomed out the software has to interpolate the screen/wacom coordinates with the zoomed out version, which may result in less optimal lines.
![lazy nezumi pro clip studio lazy nezumi pro clip studio](https://i.pinimg.com/originals/b2/3a/a9/b23aa93910d4d9d562ee093b3c00b73c.jpg)
I observed the same issue when drawing in most drawing/painting applications that are bitmap based (sometimes even vector based).